fms-like tyrosine kinase-3 mutation in a child with standard-risk all and normal karyotype
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abstract
fms-like tyrosine kinase-3 is a receptor tyrosine kinase expressed by immature hematopoietic cells and is important for the normal development of stem cells and the immune system. mutations of fms-like tyrosine kinase-3 have been detected in about 30% of patients with acute myelogenous leukemia and a small number of patients with acute lymphoblastic leukemia. the fms-like tyrosine kinase-3 mutations most often involve small tandem duplications of amino acids within the juxtamembrane domain of the receptor and are called internal tandem duplications. the other type of mutations in fms-like tyrosine kinase-3 is located in the activation loop of the second tyrosine kinase domain. multiple studies have shown that activating mutations of fms-like tyrosine kinase-3 are common in blasts from patients with aml but are rarely found in adult patients with acute lymphoblastic leukemia. in addition, activating flt3 mutations occur only rarely in t-all cases. here we report a 3-year-old girl with all who had a mutation in fms-like tyrosine kinase-3 / internal tandem duplications. keywords: fms-like tyrosine kinase-3, mutation, acute lymphoblastic leukemia, childhood.
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FMS-like tyrosine kinase-3 is a receptor tyrosine kinase expressed by immature hematopoietic cells and is important for the normal development of stem cells and the immune system. Mutations of FMS-like tyrosine kinase-3 have been detected in about 30% of patients with acute myelogenous leukemia and a small number of patients with acute lymphoblastic leukemia. The FMS-like tyrosine kinase-3 muta...
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Size: 993 amino acids; 112804 Da; FLT3 is a class III receptor tyrosine kinase (RTK) structurally related to the receptors for platelet derived growth factor (PDGF), colony stimulating factor 1 (CSF1), and KIT ligand (KL).; these RTK contain five immunoglobulin-like domains in the extracellular region and an intracelular tyrosine kinase domain splitted in two by a specific hydrophilic insertion...
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993 amino acids; FLT3 is a class III receptor tyrosine kinase (RTK) structurally related to the receptors for platelet derived growth factor (PDGF), colony stimulating factor 1 (CSF1), and KIT ligand (KL); these RTK contain five immunoglobulin-like domains in the extracellular region and an intracelular tyrosine kinase domain split in two by a specific hydrophilic insertion (kinase insert); imm...
full textبررسی جهش های ژن ( FLT3 (FMS like tyrosine kinase 3 درکودکان مبتلا به لوسمی های حاد
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Journal title:
iranian journal of blood and cancerجلد ۶، شماره ۱، صفحات ۵۱-۵۳
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